Amlong 5 mg contains Amlodipine which is a calcium channel blocker. Amlodipine is a dihydropyridine calcium antagonist that inhibits the transmembrane influx of calcium ions into the vascular smooth muscle and cardiac muscle. The mechanism of the antihypertensive action is due to a direct relaxant effect on vascular smooth muscle. The precise mechanism by which Amlodipine relieves angina may be due to the following two actions: Amlodipine dilates peripheral arterioles and thus reduces the total peripheral resistance against which the heart works. Since there is no associated reflex tachycardia this unloading of the heart reduces myocardial energy consumption and oxygen requirements and probably accounts for the effectiveness of Amlodipine in myocardial ischaemia. The mechanism of action of Amlodipine probably involves dilation of the main coronary arteries and coronary arterioles both in normal and ischaemic regions.
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