Calamine lotion has been used for centuries to relieve itchiness and discomfort from minor skin conditions such as hives or mosquito bites. It also has drying properties and it’s often used to dry out rashes caused by poisonous plants. For this reason calamine lotion may be used as an acne treatment. It can dry out a pimple eventually making it disappear. However calamine lotion isn’t a primary treatment for acne.