Daboral® contains Aminosidine Sulphate (paromomycin) which is an aminoglycoside antibiotic. Aminosidine has a broad spectrum of activity including activity against protozoa especially Entamoeba histolytica bacteria and cestodes. The drug is believed to act against both the trophozoite and encysted forms of Entamoeba. Aminosidine has an antibacterial spectrum similar to that of neomycin. Aminosidine is active against some gram-positive bacteria (e.g. some strains of Staphylococcus) and many gram-negative aerobic bacteria but generally is inactive against Pseudomonas aeruginosa and anaerobic bacteria. Aminosidine also has some activity against Mycobacterium tuberculosis. Aminosidine has been shown to be active against certain cestodes (tapeworms) pathogenic to humans including Diphyllobothrium latum (fish tapeworm) Taenia saginata (beef tapeworm) and T.solium (pork tapeworm). Daboral® is used in the treatment of intestinal protozoal infections including amoebiasis cryptosporidiosis and giardiasis. It has been used in the treatment of tapeworm infection. Also in the suppression of intestinal flora both pre-operatively and in the management of hepatic encephalopathy.
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